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Rheumatology
Metabolic syndrome: prevalence and risk factors in Korean gout patients
Jae Hyun Jung, Gwan Gyu Song, Jong Dae Ji, Young Ho Lee, Jae-Hoon Kim, Young Ho Seo, Sung Jae Choi
Korean J Intern Med. 2018;33(4):815-822. Published online October 12, 2016
Background/Aims: We performed this study to investigate associations between metabolic syndrome, chronic kidney disease (CKD), and gout.
Methods: We reviewed the medical records of 151 patients with gout at the Department of Rheumatology in Korea University Ansan Hospital. The following measures we..
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Hemato-oncology
Chronic kidney disease in the BCR-ABL1-negative myeloproliferative neoplasm: a single-center retrospective study
Seung-Woo Baek, Ji Young Moon, Hyewon Ryu, Yoon-Seok Choi, Ik-Chan Song, Hyo-Jin Lee, Hwan-Jung Yun, Samyoung Kim, Deog-Yeon Jo
Korean J Intern Med. 2018;33(4):790-797. Published online March 17, 2017
Background/Aims: Renal complications related to BCR-ABL1-negative myeloproliferative neoplasms (MPNs) have not been examined fully in Asian populations.
Methods: We analyzed estimated glomerular filtration rate (eGFR) and its changes with time retrospectively in patients with BCR-ABL1..
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Pulmonology
Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease
Woo Ho Ban, Hyeon Hui Kang, In Kyoung Kim, Jick Hwan Ha, Hyonsoo Joo, Jong Min Lee, Jeong Uk Lim, Sang Haak Lee, Chin Kook Rhee
Korean J Intern Med. 2018;33(4):745-752. Published online March 13, 2018
Background/Aims: Several studies have identified a role for nuclear factor erythroid 2-related factor 2 (Nrf2) in the development of chronic obstructive pulmonary disease (COPD). However, the relationship between the plasma Nrf2 level and the extent of systemic inflammation associated with COPD stat..
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Nephrology
Hepatitis C virus infection in chronic kidney disease: paradigm shift in management
So Mi Kim, Il Han Song
Korean J Intern Med. 2018;33(4):670-678. Published online June 28, 2018
Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated inte..
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Dasatinib induces severe hemorrhagic colitis in a patient with accelerated phase of chronic myelogenous leukemia
Eunjung Yim, Yeon-Geun Choi, Yoon-Jeong Nam, Jain Lee, Jeong-A Kim
Korean J Intern Med. 2018;33(2):446-448. Published online March 10, 2016
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Allergy
Disease-specific impairment of the quality of life in adult patients with chronic spontaneous urticaria
Won-Sun Choi, Eun-Soo Lim, Ga-Young Ban, Ji-Hye Kim, Yoo-Seob Shin, Hae-Sim Park, Young-Min Ye
Korean J Intern Med. 2018;33(1):185-192. Published online June 1, 2016
Background/Aims: Chronic urticaria (CU) is a common skin disorder characterized by wheals and pruritus lasting more than 6 weeks. Due to its long duration and changeable symptoms, the quality of life (QOL) of patients with CU can be impaired substantially. We evaluated the CU-QOL, a previously valid..
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Nephrology
Long-term prognosis of end-stage renal disease patients with normal myocardial perfusion as determined by single photon emission computed tomography
Gun Ha Park, Jae Won Song, Chang Min Lee, Young Rim Song, Sung Gyun Kim, Hyung Jik Kim, Jwa Kyung Kim
Korean J Intern Med. 2018;33(1):148-156. Published online November 22, 2016
Background/Aims: Normal myocardial perfusion is closely associated with very low rates of cardiac events and better long-term outcomes; however, little is known about its prognostic value in patients with end-stage renal disease (ESRD).
Methods: A total of 286 incident patients underwent baseline c..
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Pulmonology
Factors associated with low-level physical activity in elderly patients with chronic obstructive pulmonary disease
Sang Hee Lee, Ki Uk Kim, Haejung Lee, Yun Seong Kim, Min Ki Lee, Hye-Kyung Park
Korean J Intern Med. 2018;33(1):130-137. Published online June 7, 2017
Background/Aims: In patients with chronic obstructive pulmonary disease (COPD), the extent of physical activity (PA) is correlated with disease severity and prognosis. However, factors associated with low-level PA in elderly COPD patients are not known. We assessed the levels of PA and clinical fact..
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Gastroenterology
Large-scale surveillance study of the safety and effectiveness of entecavir in Korean patients with chronic hepatitis B
Chang Wook Kim, Chang Seop Kim, Hee Yeon Kim, Chang Don Lee, Kyungha Yu, Cyril Llamoso, Heon Ju Lee
Korean J Intern Med. 2018;33(1):91-101. Published online December 13, 2017
Background/Aims: Entecavir (ETV) is effective and safe antiviral agent against hepatitis B virus (HBV) in clinical and real-world setting but, most studies were performed in single institute or have limitation in patient’s number. A large-scale nation-wide real-world surveillance study was carried..
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Clinical implication of serum uric acid level in pegylated interferon and ribavirin combination therapy for chronic hepatitis C infection
In Soo Oh, Joung Won Won, Hyung Joon Kim, Hyun Woong Lee
Korean J Intern Med. 2017;32(6):1010-1017. Published online August 11, 2017
Background/Aims: Combined treatment of pegylated interferon-α (PEG-IFN) and ribavirin (RBV) has long been accepted as the standard treatment for chronic hepatitis C virus (HCV) infection. Many predictive factors for treatment response have been identified. The aim of this study was to evaluate the..
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Allergy
Korean version of the Cough Symptom Score: clinical utility and validity for chronic cough
Jae-Woo Kwon, Ji-Yong Moon, Sae-Hoon Kim, Woo-Jung Song, Min-Hye Kim, Min-Gyu Kang, Kyung-Hwan Lim, So-Hee Lee, Sang Min Lee, Jin Young Lee, Hyouk-Soo Kwon, Kyung-Mook Kim, Sang-Heon Kim, Sang-Hoon Kim, Jae-Won Jeong, Cheol-Woo Kim, Sang-Heon Cho, Byung-Jae Lee; Work Group for Chronic Cough, the Korean Academy of Asthma, Allergy and Clinical Immunology
Korean J Intern Med. 2017;32(5):910-915. Published online March 31, 2017
Background/Aims: The Cough Symptom Score (CSS) is a simple, useful tool for measuring cough severity. However, there is no standard Korean version of the CSS. We developed a Korean version of the CSS and evaluated its clinical utility and validity for assessing chronic cough severity.
Methods: The..
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Endocrinology-metabolism
Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus
Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
Korean J Intern Med. 2017;32(5):875-882. Published online May 31, 2017
Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM).
Methods: This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospi..
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Pulmonology
The activation of NLRP3-inflammsome by stimulation of diesel exhaust particles in lung tissues from emphysema model and RAW 264.7 cell line
Soo-Taek Uh, So My Koo, Yangki Kim, Kiup Kim, Sungwoo Park, An Soo Jang, Dojin Kim, Yong Hoon Kim, Choon-Sik Park
Korean J Intern Med. 2017;32(5):865-874. Published online August 18, 2017
Background/Aims: Diesel exhaust particles (DEPs) lead to elevation of reactive oxygen species, which can activate the nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain 3 (NLRP3)-inf lammasome. In this study, we elucidated whether NLRP3 -inf lamm..
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Nephrology
Sleep duration and chronic kidney disease: The Korean Genome and Epidemiology Study (KoGES)-Kangwha study
Hansol Choi, Hyeon Chang Kim, Joo Young Lee, Ju-Mi Lee, Dong Phil Choi, Il Suh
Korean J Intern Med. 2017;32(2):323-334. Published online February 15, 2017
Background/Aims: Sleep duration affects health in various ways. The objective of this study was to investigate the associations of sleep duration with chronic kidney disease (CKD) in a Korean adult population.
Methods: This cross-sectional analysis was conducted for total of 1,360 participants who ..
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Gastroenterology
Decreased S100B expression in chronic liver diseases
Su Jung Baik, Tae Hun Kim, Kwon Yoo, Il Hwan Moon, Ju Young Choi, Kyu Won Chung, Dong Eun Song
Korean J Intern Med. 2017;32(2):269-276. Published online June 3, 2016
Background/Aims: Hepatic innervation in liver diseases is not fully understood. We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively.
Methods: Liver specimens were obtained from 70 subjects (three c..
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Hemato-oncology
BCR-ABL1 transcripts (MR4.5) at post-transplant 3 months as an early predictor for long-term outcomes in chronic myeloid leukemia
Sung-Eun Lee, Soo Young Choi, Soo-Hyun Kim, Hye-Young Song, Hea-Lyun Yoo, Mi-Young Lee, Ki-Hoon Kang, Hee-Jeong Hwang, Eun-Jung Jang, Dong-Wook Kim
Korean J Intern Med. 2017;32(1):125-136. Published online June 22, 2016
Background/Aims: The aim of this study was to identify the role of BCR-ABL1 transcript level as a predictor for post-transplant relapse and outcome in patients who underwent allogeneic stem cell transplantation (SCT) for chronic phase (CP) chronic myeloid leukemia (CML). Methods: Of 101 patients rec..
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Nephrology
Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population
Eunhee Ji, Yon Su Kim
Korean J Intern Med. 2016;31(6):1120-1130. Published online March 25, 2016
Background/Aims: An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was..
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Duration of anuria predicts recovery of renal function after acute kidney injury requiring continuous renal replacement therapy
Hee-Yeon Jung, Jong-Hak Lee, Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Korean J Intern Med. 2016;31(5):930-937. Published online February 12, 2016
Background/Aims: Little is known regarding the incidence rate of and factors associated with developing chronic kidney disease after continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. We investigated renal outcomes and the factors associated with incomplete renal reco..
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Pulmonology
Usefulness of neutrophil to lymphocyte ratio in patients with chronic obstructive pulmonary
disease: a prospective observational study
Seung Jun Lee, Hyang Rae Lee, Tae Won Lee, Sunmi Ju, Sujin Lim, Se-Il Go, Jung-Wan You, Yu Ji Cho, Gyeong-Won Lee, Yi Yeong Jeong, Ho Cheol Kim, Jong Deog Lee
Korean J Intern Med. 2016;31(5):891-898. Published online March 25, 2016
Background/Aims: Neutrophil to lymphocyte ratio (NLR) in peripheral blood is a useful systemic inflammatory response biomarker. However, NLR has not been studied in patients with chronic obstructive pulmonary disease (COPD). This study was aimed to evaluate the usefulness of NLR in patients with COP..
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